DSIP Delta Sleep-Inducing Peptide
DSIP 5mg - Image 2

DSIP 5mg

$59.99

DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that has been extensively studied for its role in regulating sleep patterns and promoting relaxation. Its structure and unique properties have garnered interest in various fields of research, including sleep science and stress modulation.

Description

DSIP is a naturally occurring peptide found in the hypothalamus and other brain regions. It is associated with the regulation of sleep-wake cycles, stress response, and hormonal balance. Its potential effects are thought to stem from interactions with specific neurotransmitter systems, including GABAergic, serotonergic, and opioid pathways.

Key Features:

  • Sleep Regulation: Promotes natural sleep onset and enhances deep sleep (delta wave activity) while reducing REM latency.
  • Stress Reduction: Exhibits anxiolytic effects, potentially modulating stress response by reducing cortisol levels.
  • Pain Modulation: Interacts with opioid receptors, possibly contributing to pain-relief mechanisms.
  • Hormonal Balance: Studies suggest DSIP may influence the secretion of hormones such as LH (luteinizing hormone) and ACTH (adrenocorticotropic hormone).

Research Focus:

  • Investigating its role in sleep disorders, including insomnia and disrupted circadian rhythms.
  • Exploring its potential in stress-related conditions, such as anxiety and PTSD.
  • Evaluating its effects on pain management and opioid withdrawal symptoms.
  • Studying its interaction with neuroendocrine functions and its influence on metabolic processes.

This compound is intended solely for research purposes and is not approved for human consumption. It must be handled by qualified professionals within controlled laboratory environments.

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Description

DSIP (Delta Sleep-Inducing Peptide)

DSIP, or Delta Sleep-Inducing Peptide, is a synthetic analog of a naturally occurring neuropeptide first isolated from the hypothalamus. Structurally composed of 9 amino acids, DSIP is classified as a nonapeptide and has been the subject of extensive preclinical research for its potential role in sleep modulation, stress adaptation, endocrine regulation, and neuroprotection.

DSIP has been shown in animal models to modulate the function of neurotransmitters such as serotonin, GABA, and NMDA, potentially contributing to the regulation of circadian rhythms and sleep-wake cycles. Additionally, DSIP has been investigated for its possible ability to reduce oxidative stress and support homeostatic neuroendocrine balance under various physiological conditions.

Chemical Makeup

  • Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

  • Molecular Formula: C35H48N10O15

  • Molecular Weight: 848.81 g/mol

  • Solubility: Water-soluble

  • Form: Lyophilized powder

Research & Preclinical Investigations

DSIP and Sleep Regulation

In vivo studies have reported that DSIP may induce slow-wave (delta) sleep phases without affecting REM sleep duration. The peptide is believed to act on sleep-promoting regions of the hypothalamus, possibly via GABAergic and serotonergic systems. DSIP has also been shown to modulate EEG activity in rodent models, supporting its investigation as a neuropeptide of interest in circadian rhythm and sleep disorder research.

Stress Adaptation and Corticotropic Modulation

DSIP has been proposed to influence hypothalamic-pituitary-adrenal (HPA) axis activity by modulating corticotropin (ACTH) and luteinizing hormone (LH) release in animal models. These findings have prompted interest in its role in stress resistance, anxiolytic activity, and reproductive hormone balance.

Neuroprotective and Antioxidant Effects

Experimental data suggest DSIP may exhibit neuroprotective properties under conditions of oxidative stress, hypoxia, and toxic insult. Research has linked DSIP to reduced neuronal apoptosis, improved mitochondrial membrane potential, and modulation of pro-inflammatory cytokines in models of ischemic injury and neurodegeneration.

Research Use Only

DSIP is intended strictly for in vitro and in vivo laboratory research purposes. It is not approved for human use, medical therapy, or diagnostic procedures. All research involving this compound must comply with institutional safety standards and protocols.

References

  1. Monnier M, et al. Delta sleep-inducing peptide: a hypothalamic sleep factor? Neurosci Biobehav Rev. 1983;7(4):377–389.

  2. Graf MV, Kastin AJ, Coy DH. Delta sleep-inducing peptide (DSIP): effects on ACTH and LH. Peptides. 1984;5(4):741–745.

  3. Johansson B, et al. DSIP and neuroprotection: insights from hypoxia and oxidative stress models. J Mol Neurosci. 2008;36(3):317–323.

  4. Mileusnic D, et al. Modulatory role of DSIP in neurotransmission and sleep-wake regulation. Neurochem Int. 2000;36(2):145–154.

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