Description

BPC-157 & TB-500 Peptide Blend

The BPC-157 & TB-500 blend combines two regenerative peptides—BPC-157 (Body Protection Compound-157) and TB-500 (a synthetic version of the naturally occurring thymosin beta-4 fragment)—to create a synergistic compound for the study of tissue repair, angiogenesis, inflammation modulation, and cell migration in laboratory models.

Both peptides have independently demonstrated potential in accelerating wound healing, reducing inflammation, and promoting cellular regeneration in musculoskeletal and soft tissue injury models. When combined, this formulation is of particular interest in research involving connective tissue recovery, tendon and ligament repair, and neurological protection.

Chemical Makeup

• BPC-157

  • Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

  • Molecular Formula: C62H98N16O22

  • Molecular Weight: 1419.54 g/mol

• TB-500 (Thymosin Beta-4 fragment – Ac-SDKP analogue)

  • Sequence (Active region): Ac-Ser-Asp-Lys-Pro

  • Molecular Formula: C212H350N56O78S

  • Molecular Weight: ~4963.49 g/mol

• Form: Lyophilized peptide blend

• Solubility: Water-soluble (reconstitute with bacteriostatic water)

Research & Preclinical Investigations

Tissue Regeneration and Cellular Migration

In preclinical models, BPC-157 has demonstrated the ability to stimulate fibroblast migration, angiogenesis, and epithelial repair, while TB-500 promotes actin polymerization, facilitating rapid cell migration and tissue reconstruction. Together, these peptides may work synergistically to enhance the speed and quality of tissue healing, particularly in muscle, tendon, ligament, and nerve injury models.

Anti-Inflammatory and Cytoprotective Effects

Both peptides have shown anti-inflammatory properties, with studies suggesting they may downregulate TNF-α, IL-6, and other pro-inflammatory cytokines. Additionally, the blend may help protect tissues from oxidative damage and stress-induced apoptosis by supporting the cellular antioxidant response.

Angiogenesis and Blood Vessel Growth

In animal studies, BPC-157 has been linked to increased vascular endothelial growth factor (VEGF) activity and improved capillary formation. TB-500, known to upregulate angiogenesis-related gene expression, may potentiate these effects, making the blend a powerful candidate for vascular regeneration and ischemic tissue repair research.

Neurological and Organ Protection

The combined use of BPC-157 and TB-500 is under investigation for their neuroprotective potential, particularly in models of brain trauma, spinal cord injury, and gastrointestinal ulceration. The blend has also been studied in cardioprotective models, showing improved myocardial recovery following ischemic injury.

Research Use Only

This BPC-157 & TB-500 blend is intended for in vitro and in vivo research purposes only. It is not approved for human or veterinary use, therapeutic applications, or diagnostic procedures. Proper laboratory protocols and biosafety handling practices must be followed.

References

1. Sikiric P, et al. BPC 157 and blood vessel healing. Curr Pharm Des. 2018;24(18):2000–2023.

2. Goldstein AL, Hannappel E. Thymosin β4 and its synthetic derivatives as regulators of cell migration and wound healing. Ann N Y Acad Sci. 2007;1112:140–153.

3. Chang CH, et al. BPC-157 accelerates tendon healing in rat models. J Orthop Res. 2011;29(6):976–983.

4. Malinda KM, et al. Thymosin beta-4 promotes endothelial cell migration and angiogenesis. J Cell Sci. 1999;112:2045–2054.