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IGF-1 LR3 peptide vial, promoting muscle growth, fat loss, and improved recovery.
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IGF-1 LR3 1mg

Original price was: $104.99.Current price is: $94.99.

IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3)

IGF-1 LR3 is a synthetic analog of Insulin-Like Growth Factor-1 (IGF-1) with an extended half-life, designed to promote enhanced muscle growth, repair, and metabolic regulation. Its modified structure prevents binding to certain proteins in the body, increasing its biological activity and effectiveness.

Description

IGF-1 LR3 is a bioengineered peptide that mimics the natural functions of IGF-1, a hormone involved in growth and development. Its primary mechanism of action revolves around stimulating cellular proliferation and differentiation, particularly in muscle, bone, and connective tissues. Due to its extended half-life, IGF-1 LR3 remains active in the body longer than endogenous IGF-1, making it highly effective for research applications in muscle growth and metabolic regulation.

Key Features

  • Enhanced Muscle Growth: Stimulates satellite cell activation, leading to increased muscle hypertrophy and repair.
  • Cellular Regeneration: Promotes growth and regeneration of various tissues, including muscles, bones, and organs.
  • Improved Nutrient Uptake: Enhances glucose uptake and protein synthesis, optimizing energy utilization and recovery.
  • Increased Fat Metabolism: Supports lipolysis, aiding in the reduction of body fat while preserving lean muscle mass.
  • Long Half-Life: Its engineered design ensures prolonged activity, increasing its efficacy compared to regular IGF-1.

Research Focus

  • Muscle Growth and Recovery: Evaluating its potential in muscle hypertrophy, injury recovery, and age-related muscle loss (sarcopenia).
  • Metabolic Disorders: Exploring its role in glucose regulation and insulin sensitivity for diabetes research.
  • Tissue Regeneration: Studying its applications in regenerative medicine for wound healing and organ repair.
  • Performance Optimization: Investigating its effects on physical endurance, strength, and recovery in athletes (for research purposes only).

Safety and Usage

This compound is intended solely for research purposes and is not approved for human consumption. It must be handled by qualified professionals in controlled laboratory environments. Misuse or improper handling may result in unintended side effects, including hypoglycemia or hormonal imbalances. Researchers are advised to follow all applicable guidelines and protocols for safe experimentation.

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Description

IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1)

IGF-1 LR3 is a synthetic, recombinant polypeptide analog of human insulin-like growth factor-1 (IGF-1) with an amino acid substitution (arginine in place of glutamic acid at position 3) and a 13-amino acid extension at the N-terminus. This modified form, referred to as Long Arg3 IGF-1, was engineered to significantly increase the molecule’s stability and bioavailability in experimental settings.

Preclinical studies have shown that IGF-1 LR3 may exhibit enhanced potency and extended half-life compared to native IGF-1 due to reduced binding to insulin-like growth factor binding proteins (IGFBPs). This peptide is primarily used in cellular growth, differentiation, and muscle hypertrophy studies and is of growing interest in fields related to regenerative medicine, oncology, and endocrinology.

Chemical Makeup

  • Chemical Name: Long Arg3 Insulin-Like Growth Factor-1

  • Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA

  • Molecular Formula: C400H625N111O115S9 (approximate)

  • Molecular Weight: ~9,111 Da

  • Solubility: Water-soluble (pH ~6.5–7.5)

  • Form: Lyophilized powder (for reconstitution)

Research & Preclinical Investigations

IGF-1 LR3 and Cellular Growth

IGF-1 LR3 acts by binding to the IGF-1 receptor (IGF1R), a transmembrane tyrosine kinase receptor, initiating intracellular signaling cascades such as the PI3K/Akt and MAPK/ERK pathways. These pathways regulate cellular proliferation, differentiation, and survival. Research models have shown that IGF-1 LR3 promotes myoblast expansion, neuronal development, and fibroblast activation, supporting its role in tissue regeneration and growth modeling.

IGF-1 LR3 vs. Native IGF-1

Unlike endogenous IGF-1, which is rapidly sequestered by IGFBPs, IGF-1 LR3 has approximately 3–5 times the potency due to its lower binding affinity to IGFBPs. The half-life of IGF-1 LR3 in cell culture or systemic circulation is significantly extended, enabling sustained activation of target pathways and enhancing its utility in long-term in vitro and in vivo studies.

Musculoskeletal and Regenerative Research

Experimental studies in rodent and primate models have demonstrated that IGF-1 LR3 may enhance skeletal muscle hypertrophy, collagen synthesis, and bone density. It may also support satellite cell activation and angiogenesis, making it a focus in research involving injury repair, sarcopenia, and wound healing.

Research Use Only

IGF-1 LR3 is offered solely for in vitro and in vivo laboratory research. It is not approved for human consumption, clinical therapy, or diagnostic purposes. All experimental use must comply with institutional biosafety and handling protocols.

References

  1. Florini JR, Ewton DZ, Coolican SA. Growth hormone and the insulin-like growth factor system in myogenesis. Endocr Rev. 1996;17(5):481–517.

  2. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92(18):1472–1489.

  3. Barton ER. Impact of IGF-1 on muscle mass and repair: Therapeutic implications. Curr Opin Pharmacol. 2006;6(3):317–322.

  4. Hede MS, Salimova E, Piszczek L, et al. The insulin-like growth factor system in physiology and disease. Growth Horm IGF Res. 2021;56:101390.

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